Lesser Known Markers on the Organic Acids Test (OAT)

The Complex Interplay Between the Mitochondria and Oxidative Stress

Combating oxidative stress and lessening mitochondrial dysfunction are critical first steps to repair normal function. This webinar will discuss the interplay between mitochondria and oxidative stress and how to use nutritional supplements to support the mitochondria and oxidative stress.

Objectives:

1. Understand mitochondrial function and how the formation of reactive oxygen species is part of the process but destructive in excess
2. Learn about the unique vulnerability of mitochondria to oxidative stress
3. Review environmental factors that contribute to mitochondrial dysfunction and oxidative stress
4. Discuss diseases associated with mitochondrial dysfunction and oxidative stress
5. Discuss treatment options to support mitochondrial function and counteract oxidative stress

Mitochondria produce energy by creating reactive oxygen species while simultaneously being very susceptible to its damage in excess. Neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Autism along with biological aging have shown progressive failure of mitochondria and increased oxidative stress. Understanding this pathology leads to treatments to slow and prevent this destructive cycle.

Oxidative stress damage mitochondrial DNA. Damage to the mitochondrial DNA leads to abnormal proteins in the respiratory chain, increased membrane permeability and abnormal calcium homeostasis leading to further oxidative stress and finally cell death. Neurons with high energy needs have increased oxidative metabolism and are therefore extremely susceptible to this harmful cycle.