Autoimmune diseases occur when the immune system fails to distinguish self from non-self, resulting in a breach of tolerance. This heterogenous group of diseases share common genetic risk factors within the major histocompatibility complex (MHC) and HLA gene region as well as several pathophysiological mechanisms resulting in overlapping clinical manifestations which target specific organs or multiple organ systems, causing inflammation and tissue damage. Learning what gene variants might contribute toward certain autoimmune conditions can provide healthcare practitioners with ‘diagnostic insight’ for those patients already suffering from an autoimmune disorder and helps identify those most at risk due to a family history of disease and exposure to environmental risk factors
This DNA Risk test analyses thousands of gene variants within the major histocompatibility complex (MHC) and HLA gene region to report HLA typing and specific MHC gene variants related to the ten autoimmune diseases most commonly seen in clinical practice.
